ABSTRACT
BACKGROUND AND AIMS: Vitamin C has been used as an anti-oxidant in various diseases including viral illnesses like coronavirus disease (COVID-19). METHODS: Meta-analysis of randomized controlled trials (RCT) investigating the role of vitamin C supplementation in COVID-19 was carried out. RESULTS: Total 6 RCTs including n = 572 patients were included. Vitamin C treatment didn't reduce mortality (RR 0.73, 95% CI 0.42 to 1.27; I2 = 0%; P = 0.27), ICU length of stay [SMD 0.29, 95% CI -0.05 to 0.63; I2 = 0%; P = 0.09), hospital length of stay (SMD -0.23, 95% CI -1.04 to 0.58; I2 = 92%; P = 0.57) and need for invasive mechanical ventilation (Risk Ratio 0.93, 95% CI 0.61 to 1.44; I2 = 0%; P = 0.76). Further sub-group analysis based on severity of illness (severe vs. non-severe), route of administration (IV vs. oral) and dose (high vs. low) failed to show any observable benefits. CONCLUSION: No significant benefit noted with vitamin C administration in COVID-19. Well-designed RCTs with standardized control group needed on this aspect.
Subject(s)
Antioxidants/therapeutic use , Ascorbic Acid/therapeutic use , COVID-19 Drug Treatment , COVID-19/mortality , Dietary Supplements , Humans , Length of Stay , Randomized Controlled Trials as TopicABSTRACT
The second wave of Coronavirus disease (COVID-19) has wreaked havoc across the globe resulting in 3,985,022 case fatality till 06.07.2021. Due to the overburdened nature of our health care system, a sudden increase in demand for medical attention, especially, with the fast-growing number of cases every day, the present review aims to highlight the importance of yoga-based interventions as an integrative approach during COVID-19 as an add-on therapy for the treatment. A review was carried out to summarize the impact of yoga-based interventions during the pandemic COVID-19. Literature searches were conducted in PubMed from the inception of the COVID-19 pandemic till April 2021 to identify all the relevant studies. A total of 8 studies were included in the present review, which analysed heterogeneous effects of yogic exercise and breathing therapies on multitude of health benefits like respiratory muscle training, reduction of stress and depression and improvement of quality of life. This review suggests the incorporation of complementary therapies (yoga, meditation, & pranayama) for overall health improvement and well-being of patients diagnosed with COVID-19, healthcare providers, and the general public.
ABSTRACT
Background and aims Vitamin C has been used as an anti-oxidant in various diseases including viral illnesses like coronavirus disease (COVID-19) Methods Meta-analysis of randomized controlled trials (RCT) investigating the role of vitamin C supplementation in COVID-19 was carried out. Results Total 6 RCTs including n = 572 patients were included. Vitamin C treatment didn't reduce mortality (RR 0.73, 95% CI 0.42 to 1.27;I2 = 0%;P = 0.27), ICU length of stay [SMD 0.29, 95% CI -0.05 to 0.63;I2 = 0%;P = 0.09), hospital length of stay (SMD -0.23, 95% CI -1.04 to 0.58;I2 = 92%;P = 0.57) and need for invasive mechanical ventilation (Risk Ratio 0.93, 95% CI 0.61 to 1.44;I2 = 0%;P = 0.76). Further sub-group analysis based on severity of illness (severe vs. non-severe), route of administration (IV vs. oral) and dose (high vs. low) failed to show any observable benefits. Conclusion No significant benefit noted with vitamin C administration in COVID-19. Well-designed RCTs with standardized control group needed on this aspect.
ABSTRACT
BACKGROUND: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2. METHODS: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done. RESULTS: Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01-4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01-7.89, p = 0.42). CONCLUSION: No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.
Subject(s)
COVID-19 Drug Treatment , Dietary Supplements , Nutrition Therapy/methods , SARS-CoV-2/drug effects , Vitamin D/administration & dosage , Vitamins/administration & dosage , COVID-19/epidemiology , COVID-19/virology , Humans , PrognosisABSTRACT
BACKGROUND AND AIMS: The entire globe is undergoing an unprecedented challenge of COVID-19 which has affected the lifestyle behaviour of individuals. The present review is an attempt to summarize the effect of pandemic COVID-19 on lifestyle behaviour among the Indian population. METHODS: A review was carried out to summarize the effect of pandemic COVID-19 on lifestyle behaviour focusing on changes in dietary or eating behaviour, stress, sleep pattern, and level of physical activity among the Indian population. Literature searches were conducted in PubMed and Google Scholar from inception till October 2020 to identify all relevant studies. RESULTS: A total of 11 studies (n = 5957, age group 18-70 years, comprising both genders) consisting of 1 hospital and 10 community based, were included in the present review. A change in lifestyle behaviour was observed due to COVID-19. Psychosocial or any kind of mental stress among the participants was found to be prevalent. Weight gain and decline in physical activity were also observed. Not only sleep quantity but sleep quality was also found to be affected due to COVID-19. CONCLUSION: The present review indicates the need for lifestyle behaviour programmes via using the platform of E-media and also for the dissemination of health education.